NOT RECOMMENDED FOR PEOPLE WITH SEAFOOD ALLERGIES

Active Ingredients:

Glucosamine HCL 750mg
Chondroitin Sulfate (Shark) 300mg
MSM (Methylsulfonyl Methane) 200mg
Bromelain 100mg
Devils Claw (standardised 2% Harpagosides) 50mg
Horsetail (Equisetum arvense) Equiv Dry 200mg
Calcium Ascorbate 30mg
Manganese chelate 5mg Equiv to Manganese 1mg
Inactive Ingredients: Soyabean Oil, Gelatin (Halal Certified), Glycerin, Purified Water, Encapsulating Aids, Colours

As an Adult Daily Dose. Take 2 Capsules Twice Daily

RegenR8 Q&A

Q1. What is RegenR8 designed to do?
RegenR8 is designed to optimise joint function. The term joint refers to the junction or joining of two bones. Joints contain cartilage such as articular cartilage (figure 1), which acts as a cushion and minimises friction between bones during movement. Unfortunately as we age the cartilage can degenerate and/or as a consequence of injuries cartilage can be damaged. This causes abnormal stresses within the joint and consequently further degeneration of the cartilage and joint structure. This degeneration is often subjectively experienced as pain and stiffness in the effected joint. RegenR8 has been designed to optimise joint function and minimising the symptoms associated with degeneration of the joint.
Figure 1: The anatomy of a classic synovial joint.

Q2. What does RegenR8 contain?
The primary ingredients in RegenR8 are glucosamine hydrochloride and chondroitin sulphate, however RegenR8 also contains electrolytes and selected amino acids such as glutamine and glycine.

Q3. Do the ingredients in RegenR8 have any scientific backing?
Oral glucosamine has been shown in animal studies to decrease inflammation and arthritis symptoms, while it has been suggested chondroitin may inhibit cartilage degradation (Potera, 1997). More recently a number of scientific reviews have concluded that when glucosamine and chondroitin are ingested by humans they appear to have a number of beneficial effects in individuals suffering osteoarthritis (Richy et al., 2003; McAlindon, et al., 2000).
A recent clinical trial investigated the effects of glucosamine (2000mg/day) for 12 weeks in individuals experiencing regular knee pain (Braham et al., 2003). As outlined in figure 2, based on self report evaluations of changes across the 12 week supplementation period, 88% of the glucosamine group reported some degree of improvement in their knee pain versus only 17% in the placebo group. The scientists concluded that the results suggested that glucosamine supplementation can provide some degree of pain relief and improved function in persons who experience regular knee pain, which may be caused by prior cartilage injury and/or osteoarthritis.
Figure 2: percent of patients experiencing self reported improvements in knee pain during 12 weeks supplementation with either glucosamine or placebo.

Q4. Will RegenR8 reduce pain and improve joint function in every person who takes it?
It is likely to depend on the underlying cause of the pain. Joint pain should be correctly diagnosed by a qualified medical practitioner. However, as stated previously in a recent study based on self-reports during a 12-week supplementation period, 88% of the glucosamine group reported some degree of improvement in their knee pain (Braham et al., 2003). Similar beneficial effects have been reported for chondroitin in individuals suffering osteoarthritis (McAlindon, et al., 2000). Glucosamine and chondroitin are the primary ingredients in RegenR8. Therefore, while RegenR8 may not be a cure for joint pain and osteoarthritis, research would indicate that it may offer some degree of relief and functional improvement in a large percentage of individuals that trial it.

Q5. How long would it take before a patient would start to experience benefits from RegenR8?
A recent scientific review suggests that based on the analysis of a number of trials it would appear that the full therapeutic benefit of glucosamine and chondroitin may take longer than one month to experience (McAlindon, et al., 2000). In a recent glucosamine study the scientists stated "The trends in the results also suggest that, at a dosage of 2,000 mg per day, the majority of improvements are present after eight weeks" (Braham et al., 2003).

This statement illustrates that it is important not to expect results overnight. Just like when you plant a seed, just because you don't see a plant the next day does not mean that the seed is not growing. Based on the available scientific evidence, although beneficial effects may be experienced in a matter of weeks, RegenR8 may require eight weeks before beneficial effects are experienced.

Q6. Should anyone considering using RegenR8 consult a doctor prior to beginning supplementation?
Yes. Not all joint pain originates due to wear and tear of the joint cartilage. If you experience joint pain you should have it properly diagnosed to ensure that the pain is not originating from an acute (short term) or chronic (long term) injury that may need to be rehabilitated. RegenR8 will not be beneficial if you have torn a ligament or sustained a hard tissue injury (eg bone break).
RegenR8 is not a replacement of traditional therapies such as physiotherapy, but may be an excellent adjunct. As an example you may have experienced knee pain for several years and decide to see a physiotherapist.

The physiotherapist's diagnosis may indicate that you have initial signs of osteoarthritis, however they may also find that you have postural deviations that are exacerbating the problem. Together taking RegenR8 and attending several physiotherapy sessions you may be able to simultaneously treat the symptoms and the cause so as to minimise pain and future joint damage. This is an example of how RegenR8 can be part of a holistic approach to minimising or eliminating joint pain.

Q7. Is RegenR8 beneficial to athletes?
Although exercise is important to maintain optimal joint function, wear and tear and contact injuries can damage the joints cartilage. At present many elite athletes use RegenR8 so as to try and optimise cartilage health and facilitate the repair of any damage that may be sustained during training or competition.

Q8. Is RegenR8 only beneficial to athletes?
No, the ingredients in RegenR8 have been shown to benefit individuals experiencing joint pain regardless of weather they are athletes or not (Braham et al., 2003). It just so happens that many individuals who partake in intense physical training and contact sports experience some degree of joint pain over time. However, there is nothing in RegenR8 that is designed to be used exclusively by athletes.

Q9. Is RegenR8 safe?
Several recent scientific publications have reviewed the scientific research pertaining to both glucosamine and chondroitin and have concluded that both substances appear to be well tolerated (Richy et al., 2003) and safe (McAlindon, et al., 2000). Many other treatments used for osteoarthritis such as non-steroidal anti-inflammatory agents can have serious adverse effects (McAlindon, et al., 2000). Consequently, recent research suggesting that both glucosamine and chondroitin may be effective at treating osteoarthritis while being well tolerated and safe is very promising for those suffering the symptoms of osteoarthritis. In line with the scientific research no adverse effects have been reported from users of RegenR8. Individuals considering using RegenR8 should discuss their symptoms with a general practitioner to determine the best course of treatment for their condition.

Q10. Will RegenR8 cause a positive drug test?
No, RegenR8 is not a drug or banned substance. In fact none of the ingredients in RegenR8 are listed on the current. World Anti Doping Association (WADA) prohibited list (WADA, 2004). Therefore, RegenR8 can be considered a safe and legal even in elite athletes subjected to regular drug testing.

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